Honey rarely spoils: archaeologists have found jars of honey in ancient Egyptian tombs that, after three thousand years, are still safe to eat. Most other natural sweeteners, _______, break down within a few years, even when they are carefully sealed and stored.
Which choice completes the text with the most logical transition?
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Run "Classify the relationship before looking at the choices" first: honey lasts for millennia, "most other" sweeteners break down fast, so the two ideas clash head-on. That is a contrast, and "by contrast" is the only choice sitting in that family.
The first sentence says honey lasts for millennia; the second says most other sweeteners break down within a few years. Those ideas point in opposite directions, so a contrast transition is needed, and "by contrast" (A) is the only one offered. "As a result" (B) wrongly claims that other sweeteners spoil because honey lasts. "For instance" (C) would make spoiling sweeteners an example of honey's durability, which is backwards. "In other words" (D) signals a restatement, but the second sentence introduces new, opposing information rather than rephrasing the first.
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